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目的探讨芬太尼与丙泊酚联合治疗无痛人流的临床疗效。方法选择我院2011年5月～2012年12月进行人工流产的120女性,年龄22～31岁,平均25.8岁,孕龄35～60d,平均45d。随机分成对照组和观察组各60例,对照组术前1h阴道后穹隆处置米索前列醇400μg,丙泊酚2.0mg/kg静脉推注,术中追加丙泊酚0.5mg/kg;观察组在对照组的基础上芬太尼0.5μg/kg。结果观察组显效44例,有效14例,无效2例,总有效率为96.7%,对照组显效20例,有效30例,无效10例,总有效率为83.3%,观察组明显高于对照组,两组比较有显著性差异(P<0.05),观察组术中出血量为(37.6±15.6)ml,手术时间为(4.1±0.9)min,阴道出血时间(3.4±1.9)d,对照组术中出血量为(95.4±8.7)ml,手术时间为(8.2±2.1)min,阴道出血时间(6.3±2.1)d,观察组明显优于对照组,两组比较有显著性差异(P<0.05)。结论芬太尼与丙泊酚联合用药治疗无痛人流具有镇痛效果好,副作用少等优点,值得推广。
Objective To investigate the clinical efficacy of fentanyl combined with propofol in the treatment of painless abortion. Methods A total of 120 women who underwent artificial abortion from May 2011 to December 2012 in our hospital were aged 22 to 31 years with an average of 25.8 years old and 35 to 60 days of gestational age with an average of 45 days. The control group was randomly divided into control group and observation group, with 60 cases in each group. In the control group, misoprostol 400 μg and propofol 2.0 mg / kg were administered intravenously 1 hour before operation. Propofol 0.5 mg / kg was added in the observation group Fentanyl 0.5 μg / kg on the basis of the control group. Results The observation group was significantly improved in 44 cases, effective in 14 cases, ineffective in 2 cases, the total effective rate was 96.7%, the control group markedly effective in 20 cases, effective in 30 cases, ineffective in 10 cases, the total effective rate was 83.3% in the observation group was significantly higher than the control group (P <0.05). The intraoperative blood loss in the observation group was (37.6 ± 15.6) ml, the operation time was (4.1 ± 0.9) min and the vaginal bleeding time was (3.4 ± 1.9) The bleeding volume in operation was (95.4 ± 8.7) ml, the operation time was (8.2 ± 2.1) min and the time of vaginal bleeding was (6.3 ± 2.1) days. The observation group was significantly better than the control group, with significant difference between the two groups (P < 0.05). Conclusion Fentanyl combined with propofol in the treatment of painless with analgesic effect, fewer side effects, it is worth promoting.