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用病原体DNA碎片制成的疫苗前景诱人。其作用机理仍不清楚，临床试验尚无成功者。九十年代早期，海军医学研究所的斯蒂夫·霍夫曼（SieveHi）lllll；lxl）对疟疾疫苗的探索已经碰壁。霍夫曼及其同事相信，他们已鉴定出恶性疟原虫上使疫苗有效的那些部分。他们接着试用几种最新
Vaccines made with the DNA fragments of pathogens are attractive. Its mechanism of action is still not clear, no successful clinical trials. In the early nineties, the exploration of the malaria vaccine by SieveHllllllll (Naval Medical Research Institute) had run into a wall. Hoffman and his colleagues believe they have identified those parts of the Plasmodium falciparum that make the vaccine effective. They then try a few of the latest