论文部分内容阅读
对于部分直肠癌发生肝转移的患者,手术切除肝转移癌是延长其生命的最好办法。然而仍有30～40%的病人很快又出现肝内肿瘤复发。复发的可能原因之一是残肝内存在处于休眠状态的癌细胞,由于肝切除术而被激活。为此,作者对70只 BDIX 大鼠经门静脉注入一种可种植的结肠癌细胞系——DHDK 12细胞株,8周后把其中无明显肝转移癌的43只大鼠随机分为3组;第1组为对照组(n=15);第2组皮下注射环孢霉素 A 10 mg/kg/日(n=15);第3组行70%肝切除(n=13)。在注入癌细胞后12周处死,结果发现:各组肝转移癌的发生依次为3(20%)、12(80%)、8(62%)只,统计学表明第2组和第3组的发生率明显高于第1组(P<0.01,P<0.05)。
For some patients with liver metastasis in rectal cancer, surgical resection of liver metastases is the best way to extend their lives. However, 30 to 40% of patients still have recurrent intrahepatic tumors. One of the possible causes of recurrence is the presence of dormant cancer cells in the residual liver, which are activated by a hepatectomy. To this end, the authors inject 70 BDIX rats into the portal vein into a plantable colon cancer cell line, the DHDK 12 cell line. Eight weeks later, 43 rats with no obvious hepatic metastases were randomly divided into 3 groups. The first group was the control group (n=15); the second group was subcutaneously injected with cyclosporine A 10 mg/kg/day (n=15); the third group was subjected to 70% hepatectomy (n=13). After 12 weeks of injecting cancer cells, it was found that the incidence of liver metastases in each group was 3 (20%), 12 (80%), 8 (62%), and the statistics showed that the 2nd and 3rd groups The incidence was significantly higher than that of the first group (P<0.01, P<0.05).