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背景:尽管各种研究已经检验了结核菌素反应与结核病危险之间的联系,但确定在多项研究中这种联系的强度和一致性尚未得到核实和检验。 目的:对支持结核菌素反应与结核病危险之间存在联系的证据进行综述。 设计:前瞻性研究,包括根据用电子搜寻的方法查到的三个或更多的结素阳性类别的结核发病的原始资料。这些研究结果按需要重新校正并进行了比较。 结果:11项确定的研究都表明结素皮肤试验反应的增加与结核病危险性增加有联系,有几项研究发现弱结素反应与保护性作用有关。结素反应与结核病危险性之间关系的大小有很大不同。在报告最小的结素阳性反应类别里结核病发病率低的研究中,结素反应和结核病危险性的联系加大。 结论:这些研究综述结果都支持结素反应与结核病危险性之间呈正相关。但该综述发现发病危险增加程度与增大结素反应之间的联系有很大程度的不同。
Background: Although various studies have examined the link between the tuberculin reaction and the risk of tuberculosis, it has been established that the strength and consistency of this link in many studies have not yet been verified and tested. Objective: To summarize the evidence supporting the link between tuberculin reaction and tuberculosis risk. Design: Prospective studies, including original information on the incidence of TB in three or more nodule-positive categories based on the electronic search method. The results of these studies were recalibrated and compared as needed. RESULTS: All 11 defined studies showed that increased tuberculosis skin test response was associated with an increased risk of tuberculosis. Several studies have found that the weak-nociceptor response is associated with protective effects. There is a big difference in the size of the relationship between tubulointerstitial reactions and tuberculosis risk. In studies that reported a low prevalence of tuberculosis in the smallest nodule-positive response category, the link between tuberculosis and tuberculosis risk increased. CONCLUSIONS: The results of these reviews support the positive correlation between the nodin response and tuberculosis risk. However, the review found that the link between the increased risk of morbidity and the increased predictor of response was largely different.