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目的探讨归脾汤加减联合西药对血小板减少性紫癜患者的疗效。方法选取2011年1月至2014年1月70例血小板减少性紫癜患者为研究对象,抽签随机分为观察组与对照组,每组35例。观察组采用归脾汤加减联合西药治疗,对照组采用单一的西药治疗。比较两组治疗前后疗效差异及血小板计数(PLT)、血小板相关抗体G(PAIgG)、血小板相关抗体A(PAIgA)、血小板相关抗体M(PAIgM)指标的改善情况。结果观察组治疗后总有效率为91.4%,显著高于对照组的60.0%,差异有统计学意义(P<0.05);观察组治疗后PLT为(53.2±6.4)×10~9/L,显著高于治疗前及对照组治疗后,差异有统计学意义(P<0.05),PAIgG、PAIgA、PAIgM分别为(78.8±6.7)、(1.9±0.3)、(7.9±1.1)ng/10~7,显著低于治疗前及对照组治疗后,差异有统计学意义(P<0.05)。结论归脾汤加减联合西药治疗血小板减少性紫癜疗效确切,优于单一西药干预,考虑其主要通过改善血小板相关抗体发挥治疗作用。
Objective To investigate the effect of Guipi Decoction combined with western medicine on patients with thrombocytopenic purpura. Methods From January 2011 to January 2014, 70 patients with thrombocytopenic purpura were selected as the study objects. Random sampling was divided into observation group and control group with 35 cases in each group. The observation group was treated with Guipi Decoction combined with western medicine, and the control group with single western medicine. The difference of curative effect, PLT, PAIgG, PAIgA and PAIgM between two groups before and after treatment were compared. Results The total effective rate in observation group was 91.4%, which was significantly higher than that in control group (60.0%, P <0.05). The PLT in observation group was (53.2 ± 6.4) × 10 ~ 9 / L after treatment (P <0.05), PAIgG, PAIgA and PAIgM were (78.8 ± 6.7), (1.9 ± 0.3) and (7.9 ± 1.1) ng / 10 ~ 7, which was significantly lower than that before treatment and after treatment in the control group, the difference was statistically significant (P <0.05). Conclusion Guipi Decoction combined with Western medicine treatment of thrombocytopenic purpura curative effect is better than the single western medicine intervention, considering its mainly through the improvement of platelet-related antibodies play a therapeutic role.