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本文对患有“人类T细胞向淋巴性病毒Ⅰ型抗体”(HTLV I)相关的皮肤病的6例病人的临床病理特征重新作了描述.所有病人(1女,5男,平均年龄45岁)都是西印度血统,且都久居英国.其皮肤特征包括局限性丘疹(2例),全身性丘疹结节损害(3例),斑块及肿瘤(1例).5例病人在平均持续了67个月(3个月-21年)出现白血病样改变.除1例随后即死亡外,其余只存活了平均7个月.其皮肤组织学是多种多样的.大多数损害的特征是真皮层的细胞浸润,包括异常细胞及小淋巴细胞、组织细胞、浆细胞和嗜酸性粒细胞.三例病人存在亲表皮性(epidermotropism).肿瘤细胞延伸到胶原束之间〔“印度锉”(I ndianfi ling)〕且含有丰富的细胞浆和大而致密的多形核.1例病人的这些大而不典型细胞产生一种看上去象肉芽肿样的现象.从五个病人的DNA结构进行分子学研究揭示了单克隆T-细胞系列.在三个病人将相关的克隆与“人类T-细胞向淋巴性病毒Ⅰ型抗体”的前病毒
In this article, the clinicopathological features of 6 patients with dermatological disorders associated with “HTLV I” of human T cells were re-described. All patients (1 female, 5 male, mean age 45 years ) Were both of West Indo-descent origin and lived in the UK for a long time.The skin features include localized papules (2 cases), systemic papules (3 cases), plaques and tumors (1 case) A 67-month (3 months-21 years) leukemia-like change occurred, except for 1 case of subsequent death, which averaged only 7 months and varied in histology of the skin. Most lesions were characterized by Cell infiltration of the dermis, including abnormal cells and small lymphocytes, histiocytes, plasma cells, and eosinophils. Three patients had epidermotropism. Tumor cells extended between collagen bundles [ Indianfi ling)] and is rich in cytoplasm and large, dense polymorphic nuclei. The large atypical cells of one patient produced a seemingly granulomatous phenomenon. The DNA structure of five patients Molecular studies reveal a monoclonal T-cell line that will be relevant in three patients Cloning and “the human T- cell lymphotrophic virus type Ⅰ antibodies” provirus