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目的探讨过敏性患者血清螨特异性抗体水平与居室内过敏原浓度的相关性。方法选择户尘螨(d1)和/或粉尘螨(d2)血清检测结果在4～6级(中、重度)的过敏性疾病(包括过敏性哮喘、过敏性鼻炎、异位性皮炎、慢性荨麻疹)患者33例,用吸尘器吸取患者居室内枕头、被子、床垫、褥子上的灰尘,装入专用盒子;用德国Acarex公司的HDM过敏原快速检测试剂盒对尘样进行检测,根据显色反应判断尘螨过敏原浓度水平(共4级,包括阴性、低度阳性、中度阳性、高度阳性)。结果共采集尘样79份,检测结果均为阳性;其中低度阳性、中度阳性、高度阳性的检出率分别为24.1%(19份)、25.3%(20份)和50.6%(40份)。统计数据经χ2检验,差异有统计学意义(P<0.05),显示中、重度过敏性疾病患者血清螨特异性抗体水平与居室内过敏原浓度呈正相关,即患者血清螨特异性抗体水平有随着居室内过敏原浓度升高而增加的趋势。结论中、重度过敏性疾病患者血清螨特异性抗体水平与居室内过敏原浓度呈正相关,临床医生应指导患者定期清洁居室内的寝具,做好尘螨过敏原的防护工作,减少甚至切断过敏原,为患者的脱敏治疗提供帮助。
Objective To investigate the correlation between serum mite-specific antibody levels and indoor concentrations of allergens in allergic patients. Methods The serum test results of household dust mite (d1) and / or dust mite (d2) were detected in grade 4 to 6 (moderate and severe) allergic diseases including allergic asthma, allergic rhinitis, atopic dermatitis and chronic urticaria Measles) 33 patients with a vacuum cleaner to absorb the indoor living room pillows, quilts, mattresses, mattresses on the dust, into a special box; with German Acarex HDM allergen rapid detection kit for dust samples were detected according to the color Response to determine the concentration of dust mite allergen levels (a total of 4, including negative, low positive, moderate positive, highly positive). Results A total of 79 dust samples were collected and the results were positive. The detection rates of low positive, moderate positive and high positive were 24.1% (19), 25.3% (20) and 50.6% (40 ). Statistics by χ2 test, the difference was statistically significant (P <0.05), showing moderate and severe allergic disease patients with serum mite-specific antibody levels and indoor concentrations of allergens was positively correlated, that is, the level of serum mite antibody in patients with With the indoor allergen concentration increased and the trend of increasing. Conclusion The levels of serum mite-specific antibodies in patients with moderate and severe allergic diseases are positively correlated with the concentrations of indoor allergens. Clinicians should instruct patients to regularly clean the bedding in the room, protect the dust mite allergens, and reduce or even cut off allergens , For patients with desensitization treatment to help.