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目的比较不同配伍保胎药物治疗先兆早产的临床疗效。方法先兆早产病例126例,随机分组,利托君联合硫酸镁组(观察组)和沙丁胺醇联合硫酸镁组(对照组),观察两组治疗后宫缩抑制情况,起效时间、延长妊娠天数、累计用药时间、治疗效果及不良反应。结果观察组与治疗组有效抑制宫缩时间分别为(2.0±1.5)h、(4.14±1.3)h,差异有统计学意义(P<0.05),延长妊娠天数分别为(20.0±1.1)d、(13±5.8)d,差异有统计学意义(P<0.05),累计用药时间分别为(7.04±1.6)d、(7.46±1.2)d,差异无统计学意义(P>0.05),成功率分别为89.4%、51.3%,有效率分别为97.0%、78.3%,差异有统计学意义(P<0.05)。结论早产的治疗目的是控制先兆早产延长孕周,利托君联合硫酸镁作用强,显效快,避免大剂量长时间持续用药,值得在基层医院推广应用。
Objective To compare the clinical efficacy of different compatibility tocolytic drugs in the treatment of threatened preterm labor. Methods 126 patients with threatened preterm birth were randomly divided into two groups: treated with magnesium sulfate (observation group) and magnesium sulfate group (control group), observed the contractions after treatment, the onset time, prolonged days of pregnancy, Cumulative medication time, treatment and adverse reactions. Results The effective time of contractions was (2.0 ± 1.5) h and (4.14 ± 1.3) h respectively in observation group and treatment group, the difference was statistically significant (P <0.05), the number of days of prolonged pregnancy was (20.0 ± 1.1) d, (13 ± 5.8) d, the difference was statistically significant (P <0.05), the cumulative medication time was (7.04 ± 1.6) d, (7.46 ± 1.2) d, the difference was not statistically significant (P> 0.05), the success rate Respectively, 89.4%, 51.3%, the effective rates were 97.0%, 78.3%, the difference was statistically significant (P <0.05). Conclusions The purpose of treatment of preterm birth is to control the prolonged gestational age of threatened premature delivery. With the strong effect of magnesium sulfate combined with magnesium sulfate, it is effective and fast, avoiding long-term high-dose administration, which is worth popularizing and applying in primary hospitals.