目的探讨SP110基因的单核苷酸多态性(SNP)位点与肺结核易感性的关系。方法选取58例肺结核患者(试验组)和62例健康志愿者(对照组),进行SNP分型分析,比较两组SP110基因SNP位点rs2114592和rs3948464的基因型和等位基因频率。结果 rs2114592位点的基因型有3种,两组的基因型和等位基因频率差异无统计学意义(P>0.05)。rs3948464位点的基因型在两组中均为CC型,未检测到其他2种基因型。结论 SP110基因rs2114592和rs3948464位点的多态性与肺结核的易感性无关。 Objective To investigate the relationship between single nucleotide polymorphism (SNP) of SP110 gene and susceptibility to pulmonary tuberculosis. Methods Fifty-eight patients with tuberculosis (experimental group) and 62 healthy volunteers (control group) were selected for genotyping and SNP typing. The genotype and allele frequencies of SNP loci rs2114592 and rs3948464 in two groups were compared. Results There were 3 genotypes of rs2114592 locus, but there was no significant difference in genotype and allele frequencies between the two groups (P> 0.05). The genotype of rs3948464 was CC in both groups and no other two genotypes were detected. Conclusion The polymorphisms of SP110 gene rs2114592 and rs3948464 sites are not associated with the susceptibility to tuberculosis.