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目的探讨新生儿呼吸衰竭时氧合功能指标监测的临床意义。方法对在新生儿重症监护室中应用呼吸机治疗的34例呼吸衰竭患儿及30例正常新生儿,行血气分析、肺泡-动脉血氧分压差(A-aDO2)、呼吸指数(RI)、氧合指数(OI)等氧合功能指标监测,并根据病情分组进行对比观察。结果新生儿呼吸衰竭与正常新生儿比较A-aDO2、OI、RI差异有统计学意义(P<0.001);轻度呼吸衰竭组与重度呼吸衰竭组两组PaO2、A-aDO2、OI、RI差异有统计学意义(P<0.05);呼吸衰竭机械通气时间48 h内撤机组与48 h后撤机组在A-aDO2、OI、RI、PCO2差异有统计学意义(P<0.05)。结论应用氧合功能指标对新生儿呼吸衰竭的早期诊断、判断病情程度及评估预后有重要临床意义。
Objective To investigate the clinical significance of monitoring the oxygenation function index in neonatal respiratory failure. Methods Thirty-four children with respiratory failure and 30 normal newborns who were treated with ventilator in neonatal intensive care unit were enrolled. Blood gas analysis, A-aDO2, RI, , Oxygenation index (OI) oxygenation and other indicators of monitoring, and according to the disease grouping comparative observation. Results There was significant difference in A-aDO2, OI and RI between newborns with respiratory failure and normal newborns (P <0.001). PaO2, A-aDO2, OI and RI in mild respiratory failure group and severe respiratory failure group were significantly different (P0.05). There was significant difference in A-aDO2, OI, RI and PCO2 between ventilator-evacuation group and ventilator-evacuation group within 48 hours after mechanical ventilation for 48 hours (P <0.05). Conclusion The application of oxygenation function indicators of neonatal respiratory failure early diagnosis, to determine the severity of the disease and evaluate the prognosis of important clinical significance.