论文部分内容阅读
目的:评估雷帕霉素药物洗脱支架(SES)对糖尿病小型猪冠状动脉支架置入后内膜增生的作用。方法:建立链脲菌素诱导的糖尿病小型猪模型(糖尿病组,n=12),随机选取2支冠状动脉置入SES,共计置入24枚支架,术后饲养6个月,与非糖尿病置入SES支架的小型猪模型(对照组,n=12)比较冠状动脉造影、血管内超声及组织切片检查结果。结果:两组动物支架置入冠状动脉分布,术前参照血管直径[糖尿病组:(2.78±0.35)mm,对照组:(2.81±0.29)mm]及术后即刻最小管腔内径[糖尿病组:(2.90±0.42)mm,对照组:(2.89±0.33)mm]均相似(P均>0.05)。术后6个月糖尿病组支架内狭窄程度[(35.6±9.2)%和(7.9±3.1)%,P<0.001]、支架内晚期管腔丢失[(0.32±0.09)mm和(0.09±0.04)mm,P<0.001]、新生内膜厚度[血管内超声:(0.35±0.12)mm和(0.11±0.08)mm,P<0.05]及新生内膜面积[血管内超声:(1.29±0.51)mm2和(0.26±0.11)mm2,P<0.001;组织切片:(1.24±0.76)mm2和(0.19±0.08)mm2,P<0.05]均显著高于对照组。结论:糖尿病小型猪冠状动脉置入SES后内膜增生程度显著高于无糖尿病模型。
Objective: To evaluate the effect of rapamycin-eluting stent (SES) on neointimal hyperplasia after implantation of diabetic mini-swine coronary stents. Methods: Streptozotocin-induced diabetic miniature pig model (diabetic group, n = 12) was established. Two coronary arteries were randomly selected and placed in SES. A total of 24 stents were housed and were maintained for 6 months postoperatively. Mini-swine models into the SES scaffold (control group, n = 12) compared coronary angiography, intravascular ultrasound and histological examination. Results: The coronary stents were placed in two groups of animals, and the preoperative reference was made to the diameter of the blood vessels (2.78 ± 0.35 mm in the diabetes group and 2.81 ± 0.29 mm in the control group) and the smallest lumen diameter immediately after the operation [Diabetes group: (2.90 ± 0.42) mm in the control group: (2.89 ± 0.33) mm] (all P> 0.05). The degree of stent stenosis was significantly higher in patients with diabetes mellitus at 6 months after surgery (35.6 ± 9.2% vs 7.9 ± 3.1%, P <0.001), and the late stent loss was (0.32 ± 0.09) mm and (0.09 ± 0.04) mm, P <0.001], neointimal thickness [intravascular ultrasound: (0.35 ± 0.12) mm and (0.11 ± 0.08) mm, P <0.05] and neointimal area [intravascular ultrasound: (1.29 ± 0.51) mm2 And (0.26 ± 0.11) mm2, P <0.001. Tissue sections: (1.24 ± 0.76) mm2 and (0.19 ± 0.08) mm2, P <0.05] were significantly higher than those in the control group. Conclusion: Intimal hyperplasia was significantly higher in diabetic miniature pigs than in non-diabetic coronary arteries after SES implantation.