对于由幽门螺杆菌引起的胃炎及消化性溃疡,1993年由Bagglif等人提出了三联疗法,即胶体铋120毫克、灭滴灵250毫克、四环素500毫克,每日1次,疗程2周。经过几年的临床验证并与其他疗法对比后,被视为经典疗法,幽门螺杆菌根除率达到90％以上,其疗效是肯定的。然而,三联疗法存在着配伍用药不合理、毒副作用较多、多数患者难于耐受等不可忽视的问题。 For gastritis caused by Helicobacter pylori and peptic ulcer, triple therapy was proposed by Bagglif et al. In 1993, namely 120 mg of colloidal bismuth, 250 mg of metronidazole and 500 mg of tetracycline once daily for 2 weeks. After several years of clinical validation and comparison with other therapies, it is regarded as classical therapy, and the eradication rate of Helicobacter pylori reaches more than 90%. The curative effect is affirmative. However, the triple therapy there is unreasonable compatibility drugs, toxic side effects, most patients are difficult to tolerate other issues can not be ignored.