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为探索 ki-67基因产物与肾癌生物学行为及预后的关系 ,采用免疫组化 L SAB法对 60例肾细胞癌和 5例正常肾组织 ki-67表达产物进行检测。结果表明 :ki-67在正常肾组织中低表达。在全部肾癌中 ki-67均表达 ,程度不同 ,与分期、分级密切相关 (P<0 .0 0 5) ,与组织学类型无关 ;ki-67高表达者预后差。提示 ki-67可作为肾癌恶性程度及预后的估价性指标。
In order to explore the relationship between ki-67 gene product and biological behavior and prognosis of renal cell carcinoma, immunohistochemical L SAB method was used to detect the expression of ki-67 in 60 cases of renal cell carcinoma and 5 cases of normal renal tissues. The results show that: ki-67 is low in normal kidney tissue. The expression of ki-67 in all renal cell carcinoma was different with different degrees, which was closely related to staging and grading (P <0.05), but not to histological type. Ki-67 overexpression was associated with poor prognosis. Tip ki-67 can be used as a valuation indicator of malignancy and prognosis of renal cell carcinoma.