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目的 观察国产基因重组生长激素 (r-hGH)的促生长作用。方法 对 1 1例矮小症儿童使用r-hGH ,对 2例真性性早熟患儿联合应用r-hGH和促性腺激素释放激素类似物 (GnRHa) ,治疗 3个月 ,比较其治疗前后的生长速率 (GV)和身高标准差得分 (HtSDS)。结果 经治疗 ,各类矮小症儿童的GV和HtSDS均有显著提高 ,其中生长激素缺乏症患儿提高最显著 ;性早熟组儿童联用GnRHa 和r -hGH治疗时的GV略高于未用药时自然GV ,其中 1例联用时GV明显高于单用GnRHa 时GV。结论 r-hGH对各类矮小症患儿和性早熟儿童均有促生长作用
Objective To observe the growth promoting effect of domestic recombinant human growth hormone (r-hGH). Methods r-hGH was used in 11 children with short stature. The r-hGH and gonadotropin-releasing hormone analogs (GnRHa) were administered to 2 children with precocious puberty for 3 months. The growth rate before and after treatment (GV) and height standard deviation score (HtSDS). Results After treatment, the GV and HtSDS in all kinds of short stature children were significantly increased, especially in children with growth hormone deficiency. The GV in children with precocious puberty was significantly higher than that of the children without GnRHa and r-hGH Natural GV, GV in 1 case was significantly higher than that in GnRHa alone. Conclusion r-hGH can promote the growth of children with short stature and precocious puberty