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取新鲜肝癌组织、癌周肝组织和对照肝组织,测定Mn、Cu、Zn、Fe、Cd含量,同时作常规石蜡切片,HE、地衣红染色等。结果表明:Mn、Zn、Fe含量肝癌周肝组织>对照肝组织>癌组织,Cd含量癌周肝组织>癌组织,均有统计学意义。这些过量的微量元素沉积在肝细胞内,可能对肝癌的肝病背景及其病因学存在影响。Cu在癌组织内含量略高于癌周肝组织和对照肝组织,但无统计学意义。Cu、Zn含量在肝癌的癌周无纤维化肝组织>肝硬化肝癌的癌周肝组织,经统计学处理有非常显著意义和显著意义。而将肝硬化肝癌的癌周肝组织与无肝硬化肝癌的癌周肝组织、乙型肝炎与地衣红阴性肝炎的肝组织作比较,5种元素的含量均无统计学意义。
Fresh hepatocellular carcinoma, hepatic cancer tissue and liver tissue were used to determine the contents of Mn, Cu, Zn, Fe and Cd. Conventional paraffin sections, HE and lichen red staining were also performed. The results showed that the contents of Mn, Zn and Fe in hepatocellular carcinoma, hepatic liver tissue> control liver tissue> cancer tissue, and Cd content in perirenal liver tissue> cancer tissue were statistically significant. These excess trace elements are deposited in the liver cells and may have an impact on the liver disease background and etiology of liver cancer. The content of Cu in the cancer tissue was slightly higher than that in the liver tissue and the control liver tissue, but it was not statistically significant. The content of Cu and Zn in the liver tissue of the liver cancer without fibrosis liver tissue > hepatic cirrhosis liver cancer tissue, has statistically significant and significant significance. However, the contents of the five elements were not significantly different between the hepatic tissues of cirrhotic hepatocellular carcinoma and those of non-cirrhotic hepatocellular carcinoma, hepatic tissues of hepatocellular carcinoma, hepatitis B, and lichen-negative hepatitis.