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作者从美国佛罗里达州的Summerland Key附近采集一种海棉Xestopongiamuta,其粗提取物体内试验有抗肿瘤活性,并对中枢神经系统有一定作用。取新鲜海棉,以异丙醇浸泡,浓缩提取液,加水稀释,以二氯甲烷萃取,蒸去萃取液中的溶剂,将二氯甲烷可溶部分进行液-液分配分离,即以含水10%的甲醇和石油醚分配,然后加水至含水20%甲醇与四氯化碳分配,取其中四氯化碳可溶部分,经硅胶层析,即得到一种粗制不稳定的油状酸(1)(其得量为鲜海棉的0.13%),经重氮甲
The authors collected from the vicinity of Summerland Key, Florida, a sponge of Xestopongiamuta, a crude extract of which had anti-tumor activity in vivo and a central role in the central nervous system. Take fresh sponge soaked in isopropanol, the extract was concentrated, diluted with water, extracted with methylene chloride, the solvent was distilled off the extract, the methylene chloride soluble part of the liquid - liquid partition, that is, water 10 % Of methanol and petroleum ether, then add water to 20% aqueous methanol and carbon tetrachloride distribution, take the carbon tetrachloride soluble part of the silica gel chromatography to give a crude, unstable, oily acid (1 ) (Which takes 0.13% of fresh sponge), diazotized