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目的探讨肿瘤转移相关基因Mta-1、血管内皮生长因子(VEGF)在原发性肝癌组织和正常肝组织中的表达及其之间的相关性。方法免疫组化方法检测63例原发性肝癌组织和10例正常肝组织中转移相关基因(Mta-1)及血管内皮生长因子(VEGF)的表达;分析Mta-1和VEGF与原发性肝癌组织的肿瘤体积、病理类型、临床分期、淋巴结转移等临床病理参数之间的关系及Mta-1表达与VEGF的相关性。结果Mta-1与VEGF在肝癌组织中的表达阳性率均明显高于正常肝组织(χ2=10.59、6.42,P<0.01)。Mta-1在肝癌组织中的表达与肿瘤大小、临床分期、病理分级、有无淋巴结转移、有无门静脉癌栓、有无血道转移组织相关(P<0.01),VEGF在肝癌组织中的表达与临床分期、病理分级、有无淋巴结转移、有无门静脉癌栓、有无血道转移组织相关(P<0.01);在肝癌组织中Mta-1与VEGF蛋白表达呈正相关(rs=0.712,P<0.05)。结论肝癌组织中Mta-1和VEGF均呈过量表达,且二者表达存在协同促进关系,为肝癌的分子靶向治疗提供了新的靶点。
Objective To investigate the expression of Mta-1 and vascular endothelial growth factor (VEGF) in primary hepatocellular carcinoma (HCC) and normal liver tissues and their correlations. Methods Immunohistochemistry was used to detect the expression of Mta-1 and VEGF in 63 cases of primary hepatocellular carcinoma and 10 cases of normal liver tissue. The expressions of Mta-1, VEGF and primary hepatocellular carcinoma Tumor volume, pathological type, clinical stage, lymph node metastasis and other clinicopathological parameters and the relationship between Mta-1 expression and VEGF. Results The positive rates of Mta-1 and VEGF in HCC tissues were significantly higher than those in normal liver tissues (χ2 = 10.59, 6.42, P <0.01). The expression of Mta-1 in HCC was correlated with tumor size, clinical stage, histological grade, lymph node metastasis, presence or absence of portal vein tumor thrombus, and the presence or absence of hematogenous metastasis (P <0.01) There was a positive correlation between the expression of Mta-1 and VEGF in hepatocellular carcinoma (rs = 0.712, P <0.05). There was no significant difference in clinical stage, histological grade, lymph node metastasis, portal vein tumor thrombus, ). Conclusions Both Mta-1 and VEGF are overexpressed in HCC, and the expression of Mta-1 and VEGF is synergistically promoted. It provides a new target for the molecular targeted therapy of hepatocellular carcinoma.