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自身免疫性结缔组织病(OTD)的共同特点是患者血循环内有一系列针对核抗原的自身抗核抗体(ANA),这些抗哺乳动物细胞核内各种巨分子的抗核抗体在人类结缔组织病中具有相当的特异性。故ANA的检测对这些疾患的诊断、鉴别诊断、病情判断、预后估价和发病机理的研究有重要意义。 本研究应用大白鼠肝印片和人鳞状上皮癌单层培养细胞(HEP-2)作基质,对各种结缔组织疾病的ANA的敏感性和特异性进行检测和比较,现将结果报告如下。
A common feature of autoimmune connective tissue disease (OTD) is the presence of a series of autoantibodies (ANAs) directed against nuclear antigens in the bloodstream of patients. These anti-nuclear antibodies against various macromolecules in mammalian nuclei are found in human connective tissue disease Has considerable specificity. Therefore, the detection of ANA diagnosis of these disorders, differential diagnosis, disease judgment, prognosis evaluation and pathogenesis of great significance. In this study, the rat liver imprint and human squamous cell carcinoma monolayer cultured cells (HEP-2) as a matrix, a variety of connective tissue disease ANA sensitivity and specificity were detected and compared, the results reported below .