论文部分内容阅读
热休克蛋白 90作为一种应激性蛋白和伴侣蛋白 ,参与体内多种信号蛋白的成熟、折叠、活化、稳定及定位。热休克蛋白 90在心血管疾病中的作用涉及eNOS和MAPK家族。热休克蛋白 90对eNOS的作用主要通过与eNOS结合影响NO的合成 ,并调节NO与O2 之间的平衡 ;通过调节NO的产生而影响血小板的聚集 ;此外 ,热休克蛋白 90还对NO的下游蛋白sGC有直接作用。热休克蛋白 90和MAPK之间存在相互调节机制
As a stress protein and chaperone, heat shock protein 90 is involved in the maturation, folding, activation, stabilization and localization of various signaling proteins in the body. The role of heat shock protein 90 in cardiovascular disease involves the eNOS and MAPK families. The effect of heat shock protein 90 on eNOS mainly influences the synthesis of NO by binding to eNOS and regulates the balance between NO and O2. It also influences the platelet aggregation by regulating NO production. In addition, heat shock protein 90 also inhibits NO production Protein sGC has a direct effect. There is a mechanism of mutual regulation between heat shock protein 90 and MAPK