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目的:探讨前列地尔联合疏血通治疗糖尿病下肢血管病变的临床疗效。方法:将糖尿病下肢血管病变120例随机分为2组,对照组应用前列地尔注射液10ug加入生理盐水100ml滴壶中,静脉滴注;红花注射液20ml加入250ml生理盐水中静脉滴注,每日1次。治疗组应用前列地尔注射液10ug加入生理盐水100ml滴壶中,静脉滴注;疏血通注射液4ml加入250ml生理静脉滴注;2组均以21天为1个疗程。观察2组治疗前后临床症状缓解情况及下肢踝肱指数(ABI)、双侧足背动脉血流量变化。结果:治疗组总有效率90.00%,对照组总有效率75.00%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后ABI与本组治疗前比较差异均有统计学意义(P<0.05),ABI、足背动脉血流量组间比较差异有统计学意义(P<0.05)。结论:前列地尔注射液联合疏血通治疗糖尿病下肢血管病变可提高ABI值,改善足背动脉血流情况。
Objective: To investigate the clinical efficacy of alprostadil combined with Shuxuetong in the treatment of diabetic lower extremity vascular disease. Methods: Diabetic lower extremity vascular lesions 120 cases were randomly divided into two groups, the control group application of alprostadil injection 10ug saline 100ml drip pot, intravenous infusion; safflower injection 20ml added 250ml saline intravenous drip, 1 day. In the treatment group, alprostadil 10ug was added to 100ml dropper of physiological saline, and intravenous drip was administered to 4ml of Shuxuetong Injection; 250ml physiological intravenous infusion was given to both groups; The clinical symptom relief, ankle brachial index (ABI) and bilateral dorsalis pedis artery blood flow changes were observed before and after treatment in two groups. Results: The total effective rate was 90.00% in the treatment group and 75.00% in the control group. The total effective rate in the two groups was significantly different (P <0.05). The curative effect in the treatment group was better than that in the control group. There was significant difference between the two groups after ABI and before treatment (P <0.05). There was significant difference between ABI and dorsalis pedis artery blood flow (P <0.05). Conclusion: Alprostadil injection and Shuxuetong treatment of diabetic lower extremity vascular lesions can improve the ABI value, improve the dorsalis pedis artery blood flow.