目的探讨急性白血病患者化疗期间真菌感染的发生率及其相关临床分析。方法 2010年3月至2012年3月期间,我院诊治的100例急性白血病患者,化疗期间15例患者并发真菌感染,对真菌感染的发生率、危险因素,以及化疗的临床疗效及不良反应,进行回顾性分析。结果 100例急性白血病患者中,化疗期间15例并发真菌感染,其发生率为15.0%。年龄和应用广谱抗生素是急性白血病化疗期间并发真菌感染的高危因素。15例并发真菌感染患者,经过伊曲康唑治疗后,13例有效,有效率为86.7%,治疗期间出现2例胆红素升高、心功能不全等药物相关不良反应,经过相应处理后,均恢复正常。结论对于急性白血病患者,化疗期间容易并发真菌感染,伊曲康唑治疗疗效显著,成为治疗的首选药物。 Objective To investigate the incidence of fungal infection in patients with acute leukemia during chemotherapy and its related clinical analysis. Methods From March 2010 to March 2012, 100 patients with acute leukemia diagnosed and treated in our hospital and 15 patients during chemotherapy were complicated with fungal infection. The incidence of fungal infection, risk factors, clinical efficacy and adverse reactions of chemotherapy were analyzed. Retrospective analysis. Results Among the 100 patients with acute leukemia, 15 cases were complicated with fungal infection during chemotherapy, the incidence was 15.0%. Age and Application Broad-spectrum antibiotics are risk factors for concurrent fungal infections during acute leukemia chemotherapy. Fifteen patients with fungal infection, after itraconazole treatment, 13 cases were effective, the effective rate was 86.7%, during treatment there were two cases of bilirubin, cardiac dysfunction and other drug-related adverse reactions, after the corresponding treatment, All returned to normal. Conclusions In patients with acute leukemia, it is easy to be complicated with fungal infection during chemotherapy. Itraconazole has a significant therapeutic effect and has become the drug of choice for treatment.