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目的:观察多西他赛联合中药丹参治疗乳腺癌的临床疗效和不良反应。方法:入选本院2009年1月-2013年12月确诊为乳腺癌的患者60例,治疗组30例给予多西他赛75 mg/(m2·d)静脉滴注,滴注1 h,合并丹参注射液1×10-1g/mL,对照组30例,单独给予多西他赛静脉滴注治疗。所有病例治疗周期均为4周,化疗2个周期后进行疗效分析。结果:治疗组完全缓解(CR)为12.9%,部分缓解(PR)为41.9%,稳定(SD)为29.0%,进展(PD)为16.1%,总有效率为54.8%,对照组总有效率为41.4%,两组差异具统计学意义(P<0.05),两组比较Ⅰ度~Ⅳ度白细胞减少数量分别为15(48.3%)和22(75.8%),两组差异具统计学意义(P<0.05),恶心呕吐的数量分别为15(48.3%)和24(82.7%),差异具统计学意义(P<0.05)。结论:多西他赛联合中药治疗乳腺癌疗效确切,不良反应可耐受,并且改善循环,可有效防止乳腺癌术后并发症。
Objective: To observe the clinical efficacy and side effects of docetaxel combined with Salvia miltiorrhiza in the treatment of breast cancer. Methods: 60 patients diagnosed with breast cancer in our hospital from January 2009 to December 2013 were enrolled. 30 patients in the treatment group were given docetaxel 75 mg / (m2 · d) intravenously and dripped for 1 h. Danshen injection 1 × 10-1g / mL, the control group of 30 patients were given docetaxel alone intravenously. All cases were treated for 4 weeks, 2 cycles after chemotherapy for efficacy analysis. Results: The complete remission (CR) was 12.9%, the partial remission (PR) was 41.9%, the stability was 29.0%, the progress was 16.1%, the total effective rate was 54.8%. The total effective rate (41.4%). The difference between the two groups was statistically significant (P <0.05). The number of Ⅰ ~ Ⅳ grade leukopenia was 15 (48.3%) and 22 (75.8% P <0.05). The number of nausea and vomiting was 15 (48.3%) and 24 (82.7%) respectively, with statistical significance (P <0.05). Conclusion: Docetaxel combined with traditional Chinese medicine treatment of breast cancer exact effect, adverse reactions can be tolerated, and improve circulation, can effectively prevent postoperative complications of breast cancer.