环戊力复霉素是治疗结核病的新物,它在体内的分布浓度直接影响对各器官结核病变的疗效。该药服后4～8小时为血中浓度高峰期。本实验用DL-473给犬口服,4小时后采用生物学方法测定其在各脏器中的分布状况。材料与方法一、实验动物:用健康草犬分甲、乙两组。 1.实验甲:雌、雄犬各一只,用DL-473 30mg/kg一次空腹灌胃,4小时后处死,取各脏器组织分别均分为2份,一份由华山医院抗生素室测定,另一份 Cycloheximide is a new treatment of tuberculosis, its distribution in the body directly affects the efficacy of tuberculosis in various organs. The drug 4 to 8 hours after the peak concentration of blood. The experiment with DL-473 to the dogs oral administration, 4 hours after the use of biological methods to determine its distribution in various organs. Materials and methods First, experimental animals: A healthy grass dog points A, B two groups. 1. Experiment A: Female and male dogs each were given an empty stomach once a day with DL-473 30mg / kg and sacrificed after 4 hours. The tissues of each organ were divided into two groups, one was determined by the antibiotics room of Huashan Hospital Another copy