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目的 :探讨原发性高血压 (EH)代谢综合征与血管紧张素转换酶 (ACE)基因插入 /缺失多态性的关系。方法 :选取EH患者 2 0 2例 ,其中男 116例 ,女 86例 ,年龄 30～ 72 (5 9.5 4± 9.2 6 )岁。符合代谢综合征者 10 6例 ,非代谢综合征 96例。应用聚合酶链反应 (PCR)测定两组ACE基因插入 /缺失多态性。结果 :EH代谢综合征组与非代谢综合征组ACE基因DD、ID、II基因型间无显著相关性 (χ2 =2 .5 4 5 ,P 0 .0 5 )。代谢综合征组ACE多态性基因型与腰围、高密度脂蛋白胆固醇 (HDL C)密切相关 (P <0 .0 1) ;与腰围 /臀围、三酰甘油 (TG)密切相关 (P <0 .0 5 ) ;与血压、血糖、胰岛素无关 (P 0 .0 5 )。代谢综合征组ACE基因DD、ID基因型腰围较II基因型显著增加 (P <0 .0 1,<0 .0 5 ) ;DD基因型腰围 /臀围、TG较II基因型显著增加 (P <0 .0 5 ) ;ACE基因DD基因型HDL C较II基因型显著降低 (P <0 .0 5 ) ;ACE基因DD、ID、II基因型间血压、血糖、胰岛素差异无统计学意义 (P 0 .0 5 )。结论 :EH代谢综合征与ACE基因多态性无显著相关性。但是代谢综合征患者肥胖、脂代谢紊乱与ACE基因多态性密切相关 ,而血压水平、胰岛素敏感性却与ACE基因多态性无关。
Objective: To investigate the relationship between essential hypertension (EH) metabolic syndrome and angiotensin converting enzyme (ACE) gene insertion / deletion polymorphisms. Methods: A total of 202 EH patients were selected, including 116 males and 86 females, ranging in age from 30 to 72 (5 9.54 ± 9.26) years. Metabolic syndrome in 106 cases, non-metabolic syndrome in 96 cases. Polymerase chain reaction (PCR) was used to detect ACE gene insertion / deletion polymorphisms in both groups. Results: There was no significant correlation between ACE genotype DD, ID, and II genotype in EH metabolic syndrome group and non-metabolic syndrome group (χ2 = 2.545, P <0.05). The genotypes of ACE polymorphism in metabolic syndrome group were closely related to waist circumference and high density lipoprotein cholesterol (HDL C) (P <0.01), and were closely related to waist circumference / hip circumference and triglyceride (TG) (P < 0 .0 5); not related to blood pressure, blood glucose and insulin (P 0 .0 5). In the metabolic syndrome group, the waist circumference of ACE gene DD and ID genotypes were significantly higher than those of genotype II (P <0.01, <0.05); The waist circumference / hip circumference of DD genotype was significantly higher than that of genotype II <0. 05). The HDL C of DD genotype of ACE gene was significantly lower than that of genotype II (P <0.05). There were no significant differences in the blood pressure, blood glucose and insulin among the DD genotypes of ACE gene P 0 .0 5). Conclusion: There is no significant correlation between EH metabolic syndrome and ACE gene polymorphism. However, patients with metabolic syndrome obesity, lipid metabolism and ACE gene polymorphism is closely related to the level of blood pressure, insulin sensitivity but ACE gene polymorphism has nothing to do.