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目的了解西藏林芝地区正常人群中流行性乙型脑炎(乙脑)病毒隐性感染情况,为制定乙脑防控措施提供依据。方法用容量比例概率抽样法,采集墨脱和察偶两县正常人群血清标本350份,用酶联免疫吸附试验(ELISA)检测乙脑IgG抗体,并对结果进行分析。结果林芝地区正常人群中,乙脑病毒IgG抗体阳性率7.7%(27/350)。男女性别、2个县间乙脑IgG抗体阳性率差异均无统计学意义;但墨脱的不同乡镇间差异有统计学意义。17~46岁组乙脑IgG抗体阳性率明显高于其他年龄组。结论林芝地区正常人群中存在一定程度的乙脑隐性感染,察偶和墨脱县可能是乙脑自然疫源地。加强传播媒介所带病毒的监测,比较传播媒介与患者病毒之间的生物学差异,对乙脑疫情防控意义重大。
Objective To understand the latent infection of Japanese encephalitis (JE) virus in normal population of Linzhi area in Tibet and provide evidence for the prevention and control of JE. Methods A total of 350 serum samples from the normal population of Medog and Tsakou were collected by the proportional probability sampling method. The IgG antibodies against JEV were detected by enzyme linked immunosorbent assay (ELISA), and the results were analyzed. Results In the normal population of Nyingchi region, the positive rate of Japanese encephalitis virus IgG was 7.7% (27/350). There were no significant differences in the positive rates of IgG between two sexes in men and women, but there was significant difference among different villages and towns in Medog. The positive rate of IgG antibody in JE from 17 to 46 years old was significantly higher than that of other age groups. Conclusion There is a certain degree of latent latent infection of JE in the normal population of Nyingchi area. Tsang Ou and Medog may be the natural foci of JE. To strengthen the monitoring of the virus in the transmission media and to compare the biological differences between the transmission media and the patients’ viruses is of great significance in the prevention and control of the JE epidemic.