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志贺菌属(Shigella)是引起全球范围内细菌性痢疾的重要病原菌.近年来,多重耐药型和新血清型志贺菌的不断出现给志贺菌的监测和防控带来了新的挑战.基因组学的快速发展为深入了解志贺菌的进化来源、变异机制及传播规律等提供了极大的帮助,对控制细菌性痢疾的蔓延具有重要的科学意义.本文首先从遗传来源角度探讨志贺菌与大肠杆菌的进化关系及其可能的分子机制,随后对福氏、宋内和1型痢疾志贺菌的基因组进化进展进行了总结,详细描述了它们的时空分布特点以及耐药基因变异在进化中所发挥的作用,以期为志贺菌的研究和防控提供参考.
Shigella is an important pathogen that causes bacillary dysentery in the world.In recent years, the emergence of multi-drug resistant strains and new serotype Shigella has brought new to Shigella monitoring and control Challenges The rapid development of genomics has provided great help for understanding the origin, mechanism of variation and propagation of Shigella, and has important scientific significance for controlling the spread of bacillary dysentery.Firstly, Shigella and Escherichia coli evolutionary relationships and possible molecular mechanisms, followed by the evolution of the genome of Shigella flexneri, Song and Shigella dysenteriae type 1 were summarized, described in detail their spatial and temporal distribution characteristics and resistance genes The role of variation in evolution is to provide a reference for the research and prevention and control of Shigella.