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目的探讨survivin基因表达与胃癌生物学行为及与cyclinD1表达的关系。方法利用免疫组化S-P法检测50例胃癌和24例慢性胃炎中survivin和cyclinD1的表达。结果Survivin和cyclinD1的阳性检测率分别为66%(33/50)和64%(32/50),survivin和cyclinD1的阳性表达与胃癌组织学类型相关(P<0.05,P<0.01),survivin表达与淋巴结转移有关,survivin的阳性表达与cyclinD1的阳性表达呈正相关。survivin和cyclinD1的高表达均与患者术后<3年生存期相关(P<0.01,P<0.05))。结论Survivin和cyclinD1基因在胃癌的发生、发展中起着不同的作用,它们的检测对胃癌恶性程度的判定、预后和进一步治疗提供有效的依据。
Objective To investigate the relationship between survivin gene expression and biological behavior and cyclinD1 expression in gastric cancer. Methods The expressions of survivin and cyclinD1 in 50 cases of gastric cancer and 24 cases of chronic gastritis were detected by immunohistochemical S-P method. Results The positive rates of survivin and cyclinD1 were 66% (33/50) and 64% (32/50), respectively. The positive expressions of survivin and cyclinD1 were correlated with histological types of gastric cancer (P <0.05, P <0.01) Correlation with lymph node metastasis, the positive expression of survivin and cyclinD1 positive expression was positively correlated. The high expressions of survivin and cyclinD1 were associated with less than 3 years of postoperative survival (P <0.01, P <0.05). Conclusion Survivin and cyclinD1 play different roles in the development and progression of gastric cancer. Their detection may provide an effective basis for the judgment, prognosis and further treatment of gastric cancer.