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目的探讨输尿管镜下钬激光碎石术对输尿管结石患者应激反应及肾功能的影响。方法选取2015年10月—2016年10月收治的输尿管结石患者130例,随机分为两组,各65例。两组均行输尿管镜下手术,其中对照组采用气压弹道碎石术,观察组采用钬激光碎石术。比较两组应激反应指标、肾功能指标及治疗效果。计量资料比较采用t检验,P<0.05为差异具有统计学意义。结果观察组术后24 h血清Cor、MDA水平[(245.38±27.95)ng/ml、(6.58±1.46)nmol]低于对照组[(270.93±28.54)ng/ml、(9.73±1.82)nmol],SOD水平[(71.23±15.74)NU/m L]高于对照组[(65.62±13.28)NU/m L],差异有统计学意义(均P<0.05);术后1个月,观察组血肌酐与尿素氮水平[(94.63±12.49)μmol/L、(4.69±1.65)mmol/L]均低于对照组[(102.63±17.42)μmol/L、(7.37±1.87)mmol/L],差异有统计学意义(均P<0.05)。结论输尿管镜下钬激光碎石术可有效治疗输尿管结石,可显著降低应激反应,改善患者术后肾功能。
Objective To investigate the effect of ureteroscopic holmium laser lithotripsy on stress response and renal function in patients with ureteral calculi. Methods 130 patients with ureteral calculi admitted from October 2015 to October 2016 were randomly divided into two groups of 65 patients. Ureteroscopic surgery was performed in both groups, including pneumatic lithotripsy in the control group and holmium laser lithotripsy in the observation group. The stress response indexes, renal function indexes and therapeutic effects were compared between the two groups. Measurement data using t test, P <0.05 for the difference was statistically significant. Results The levels of Cor and MDA in the observation group at 24 h after operation were lower than those in the control group [(245.38 ± 27.95) ng / ml, (6.58 ± 1.46) nmol] [(270.93 ± 28.54) ng / ml, , The level of SOD [(71.23 ± 15.74) NU / m L] was significantly higher than that of the control group [(65.62 ± 13.28) NU / m L] (all P <0.05) Serum creatinine and blood urea nitrogen level were significantly lower than those in the control group [(94.63 ± 12.49) μmol / L, (4.69 ± 1.65) mmol / L] The difference was statistically significant (all P <0.05). Conclusion Ureteroscopic holmium laser lithotripsy can effectively treat ureteral calculi, which can significantly reduce the stress response and improve postoperative renal function.