非甾体抗炎药(NSAIDs)通过抑制环氧化酶(COX),以减少花生四烯酸转化成前列腺素(PG)等炎症介质,达到抗炎镇痛的目的,是目前疼痛治疗的常用药物。非选择性的NSAIDs几乎都是口服型,虽能同时阻断COX-1和COX-2,起到抗炎和止痛作用,但胃肠道、肾脏和血小板等的不良反应却限制其进一步 Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in the treatment of pain by inhibiting cyclooxygenase (COX) to reduce the conversion of arachidonic acid to inflammatory mediators such as prostaglandins (PGs) to achieve anti-inflammatory and analgesic effects drug. Non-selective NSAIDs are almost always oral, although they can both block COX-1 and COX-2, and have anti-inflammatory and analgesic effects. However, adverse reactions such as gastrointestinal tract, kidneys and platelets limit their further