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目的:观察白芍总苷(TGP)联合氯沙坦钾治疗慢性肾炎蛋白尿的作用。方法:选取本院诊断的慢性肾炎患者65例,随机分为2组,治疗组予TGP600mg,每日2次口服;氯沙坦钾100mg,每日1次口服;对照组为氯沙坦钾100mg,每日1次口服。比较两组患者治疗前后的24h尿蛋白定量(UPRO)变化。结果:两组患者治疗前后UPRO均明显下降,差异有统计学意义(P<0.05),而治疗组UPRO较对照组下降的更明显,差异有统计学意义(P<0.05)。结论:白芍总苷联合氯沙坦钾能更有效降低慢性肾炎患者的尿蛋白。
Objective: To observe the effect of total glucosides of paeony (TGP) and losartan potassium on chronic nephritis proteinuria. Methods: Sixty-five patients with chronic nephritis diagnosed in our hospital were randomly divided into two groups. The treatment group was treated with TGP600mg orally twice daily, losartan potassium 100mg orally daily, losartan potassium 100mg , 1 day orally. 24 h urinary protein (UPRO) changes before and after treatment were compared between the two groups. Results: The UPRO of both groups before and after treatment decreased significantly (P <0.05), while the UPRO of treatment group decreased more significantly than that of control group (P <0.05). Conclusion: Total glucosides of paeony root combined with losartan potassium can reduce urinary protein in patients with chronic nephritis more effectively.