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通过丙交酯开环聚合制备聚乳酸(PLA)的大分子链转移剂,选用4-乙烯基苯硼酸(VBA)、甲基丙烯酸二甲氨基乙酯(DMAEMA)为功能单体,通过一步法和两步法可逆加成-断裂链转移聚合(RAFT),分别制备聚乳酸-b-(聚甲基丙烯酸二甲氨基乙酯-co-聚乙烯基苯硼酸)〔PLA-b-(PDMAEMA-co-PVBA)〕和聚乳酸-b-聚甲基丙烯酸二甲氨基乙酯-b-聚乙烯基苯硼酸(PLA-b-PDMAEMA-b-PVBA)。对聚合物的结构和其组装纳米粒子进行测试,发现结构和组装行为可控;选择性溶剂中,PLA-b-(PDMAEMA-co-PVBA)可自组装形成胶束,PLA-b-PDMAEMA-bPVBA仅在葡萄糖的参与下形成胶束。考察了聚合物在不同糖浓度下的刺激响应,结果表明,葡萄糖刺激作用下,两种聚合物胶束对葡萄糖均具有响应性,改变葡萄糖的浓度可促使纳米粒子的粒径和形貌发生变化。
The macromolecular chain transfer agent of polylactic acid (PLA) was prepared by ring-opening polymerization of lactide, using 4-vinylbenzene boronic acid (VBA) and dimethylaminoethyl methacrylate (DMAEMA) as functional monomers. And two-step reversible addition-fragmentation chain transfer polymerization (RAFT) to prepare polylactic acid-b- (dimethylaminoethylmethacrylate-co-polyvinylbenzene boronic acid) [PLA- co-PVBA)] and polylactic acid-b-poly (dimethylaminoethyl methacrylate) -b-polyvinylbenzeneboronic acid (PLA-b-PDMAEMA-b-PVBA). The structure and assembly of the polymer nanoparticles were tested and the structure and assembly behavior were found to be controllable. Among the selective solvents, PLA-b- (PDMAEMA-co-PVBA) could self-assemble into micelles and PLA-b-PDMAEMA- bPVBA forms micelles only with the involvement of glucose. The stimulus response of the polymer at different sugar concentrations was investigated. The results showed that both polymer micelles were responsive to glucose under glucose stimulation. Changing the glucose concentration could change the size and morphology of the nanoparticles .