常规病理诊断工作中常可遇到一些皮肤、粘膜的活检,很难确定为良性鳞状上皮增生、乳头瘤抑或是高度分化的鳞状细胞癌。有时甚至重复多次活检也不能肯定病变的性质,以致造成病人痛苦及延迟确诊。除取材不当或组织过少等原因外,往往是由于对一些鳞癌可表现高分化的组织形态认识不足。病理书籍及文献中有关两者的鉴别标准也很少描述或不够明确,大多凭工作经验来 Routine pathological diagnosis can often encounter some skin, mucosal biopsy, it is difficult to determine the benign squamous cell hyperplasia, papilloma or highly differentiated squamous cell carcinoma. Sometimes even repeated multiple biopsies can not confirm the nature of the disease, resulting in patient suffering and delayed diagnosis. In addition to improper or too few organizations and other reasons, often due to some squamous cell carcinoma can show highly differentiated tissue morphology lack of understanding. Pathological books and literature on the distinction between the two standards are rarely described or not clear enough, mostly based on work experience to