论文部分内容阅读
目的:调查氯氮平引起脑电图异常率和癫疒间发生率,及相关影响因素。方法:共调查331例服氯氮平后且在电休克治疗1个月外有脑电图的病历。结果:脑电图的异常率是30.21%(100/331),癫疒间发生率为0.91%(3/331)。在≤450mg/d剂量范围内,脑电图异常率以及异常程度随剂量增加而增加,差异具有统计学意义。服氯氮平后半月内以及2年以上的脑电图异常率比其他时间低。结论:服用氯氮平治疗患者的脑电图异常率高达30.21%,癫疒间发生率为0.91%。在一定剂量范围内脑电图异常率及异常程度随氯氮平剂量增加而增加。脑电图异常率差异随服用氯氮平时间不同而不同。
OBJECTIVE: To investigate the incidence of electroencephalogram abnormalities and epilepsy caused by clozapine and related factors. Methods: A total of 331 cases of clozapine taken after electroshock treatment and electroencephalogram 1 month outside the EHR medical record. Results: The abnormal rate of EEG was 30.21% (100/331) and the incidence of epilepsy was 0.91% (3/331). In the range of ≤450mg / d, EEG abnormality rate and abnormality increased with the increase of dose, the difference was statistically significant. Clozapine within half a month and more than 2 years after the EEG abnormal rate lower than other times. Conclusion: The abnormal rate of EEG in patients taking clozapine was as high as 30.21% and the incidence of epilepsy was 0.91%. In a certain range of dose EEG abnormal rate and abnormalities with the dose of clozapine increased. Differences in EEG abnormalities vary with the time of taking clozapine.