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目的探讨中药蛋白灵冲剂治疗肾病综合征的临床疗效。方法64例病程3个月~4年的肾病综合征患者,随机分为对照组(n=32)潘生丁+强地松治疗。治疗组(n=32)蛋白灵冲剂+强地松治疗、蛋白灵冲剂每次 10g,每日 2次, 8周为 1疗程。使用血液流变学测定仪及BMZ—T生物数据计算机检测血液流变学各指标。用全自动生化分析仪测出总胆固醇、甘油三酯、低密度脂蛋白。同时检测尿常规。治疗前后进行比较。结果治疗组各项指标的下降较对照组明显。其中胆固醇、甘油三酯、低密度脂蛋白有效率分别为94.6%、92.4%、94.7%。治疗组血液流变学各项指标与对照组有显著性差异(P<0.01)。结论蛋白灵以丹参、当归、水蛙等活血化瘀中药为主,佐以黄芪降蛋白尿,可缓解肾小球硬化、增加肾血流量、消减蛋白尿,使肾小球基底膜修复,并使受损肾脏组织细胞恢复,是治疗肾病综合征的良药。
Objective To investigate the clinical efficacy of Chinese medicine Bai Ling Granules in the treatment of nephrotic syndrome. Methods Sixty-four patients with nephrotic syndrome with a duration of 3 months to 4 years were randomly divided into control group (n = 32), dipyridamole + prednisone treatment. Treatment group (n = 32) Bai Ling Ling granules + prednisone treatment, protein Ling granules 10g, 2 times a day, 8 weeks for a course of treatment. Hemorheology indexes were detected by using the hemorheology analyzer and BMZ-T biological data computer. Total cholesterol, triglycerides, and low-density lipoproteins were measured with an automatic biochemical analyzer. Urine routine testing at the same time. Before and after treatment were compared. Results The treatment group decreased significantly than the control group. Among them, the effective rates of cholesterol, triglyceride and low-density lipoprotein were 94.6%, 92.4% and 94.7% respectively. The indexes of hemorheology in treatment group were significantly different from those in control group (P <0.01). CONCLUSION Proteins are mainly traditional Chinese herbs such as Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and Water Frog, which are combined with astragalin to reduce proteinuria. It can relieve glomerular sclerosis, increase renal blood flow, reduce proteinuria, and repair glomerular basement membrane. So that damaged kidney tissue cells recovery, is the treatment of nephrotic syndrome medicine.