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自从Herney Dale等在麦角的提取液中发现组织胺并研究了它的作用以来已经半个世纪了。组织胺在过敏性反应中的作用早已被肯定,同时并认为组织损伤时所产生的血管、平滑肌和腺体的反应亦与组织胺有关。虽然组织细胞释放的细胞外组织胺似乎参与小血管、平滑肌和分泌盐酸的胃腺的正常机能活动的调节,但有关这些调节的实验证据并未获得。本文所涉及的工作提出了机体细胞内组织胺的一种新的代谢性机能,认为使组氨酸形成组织胺的组氨酸脱羧酶的过度增加可能与某些快速组织生长(rapid tissue growth)有关。
It has been half a century since Herney Dale discovered histamine in the extract of ergot and studied its effects. Histamine in the role of anaphylaxis has long been affirmed, at the same time that the tissue damage caused by vascular, smooth muscle and glandular response is also related to histamine. Although extracellular histamine released by tissue cells appears to be involved in the regulation of normal functional activity of small blood vessels, smooth muscle, and gastric glands secreting hydrochloric acid, experimental evidence regarding these modulations has not been obtained. The work involved in this article presents a new metabolic function of histamine in the body’s cells and suggests that the excessive increase of the histidine decarboxylase that makes histidine to form histamine may be associated with some rapid tissue growth related.