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目的探讨血清骨钙素(OC)在多囊卵巢综合征(PCOS)患者中的水平及对PCOS诊疗的临床意义。方法选取2015年1月至2015年6月检查不孕不育且被确诊为PCOS患者60例,设为观察组;同时选取经检查确定为健康女性60例,设为对照组,入选标准为女性排卵功能正常,且雄激素指标较低,符合健康水平。对两组对象的雌二醇(E2)、黄体生成素(LH)、睾酮(T)、卵泡刺激素(FSH)、垂体泌乳素(PRL)等性激素指标和空腹胰岛素(FINS)、空腹血糖(FBG)等代谢指标水平进行检测,并测算其体质量指数(BMI)、稳态模型胰岛素抵抗指数(HOMA-IR)以及LH/FSH比值。通过酶免疫荧光法(Pharmacia CAP系统)测定两组对象的血清骨钙表达水平。结果观察组FSH、LH/FSH比值、FINS、FBG和HOMA-IR水平均高于对照组(P<0.05),E2、LH、T和PRL水平则明显低于对照组,差异有统计学意义(P<0.05);PCOS患者骨钙素水平与睾酮浓度呈正相关,与稳态模型胰岛素抵抗指数呈负相关。结论 PCOS患者骨钙素表达较低,是影响高雄激素血症和胰岛素抵抗的重要因素,推测其可能参与PCOS疾病发展。
Objective To investigate the level of serum osteocalcin (OC) in patients with polycystic ovary syndrome (PCOS) and its clinical significance in diagnosis and treatment of PCOS. Methods Sixty patients with infertility and PCOS diagnosed from January 2015 to June 2015 were selected as the observation group. Sixty healthy women were selected as the control group and were selected as female Ovulation normal, and low androgen indicators, in line with the health level. The levels of estrogen (E2), LH, T, FSH and PRL, fasting insulin (FINS) and fasting blood glucose (FBG) FBG) were measured, and their body mass index (BMI), homeostasis model insulin resistance index (HOMA-IR) and LH / FSH ratio were calculated. Serum bone calcium levels were measured by enzyme immunofluorescence (Pharmacia CAP system) in both groups. Results The levels of FSH, LH / FSH, FINS, FBG and HOMA-IR in the observation group were significantly higher than those in the control group (P <0.05). The levels of E2, LH, T and PRL in the observation group were significantly lower than those in the control group P <0.05). The level of osteocalcin in PCOS patients was positively correlated with testosterone concentration, and negatively correlated with insulin resistance index of steady-state model. Conclusions The low expression of osteocalcin in patients with PCOS is an important factor affecting hyperandrogenism and insulin resistance, suggesting that it may be involved in the development of PCOS.