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本文对26例再障的发病机制分别用GM-CFU、CFU-F及BFU-E培养方法进行了研究.发现在发病机制上多因素同时存在的复合型明显多于一个因素的单纯型;有干细胞缺损的病例最多,微环境缺陷者亦不少见;有细胞抑制的两例,其抑制可能来自单核巨噬细胞.在CFU-F减低组中循环免疫复合物(CIC)升高的病例不比CFU-F正常组中CIC升高的病例明显增多,未能说明CIC升高和造血微环境缺陷有关.在干细胞缺损型的再障中,同时存在两种祖细胞的异常(GM-CFU;BFU-E),提示其缺陷乃发生在多向造血祖细胞水平或其以上的水平.最后还对现用的4组分型法在再障发病机制研究中的作用进行了评价,并提出进一步研究的意见.
In this paper, the pathogenesis of 26 cases of aplastic anemia were respectively studied by GM-CFU, CFU-F and BFU-E culture methods.It is found that there are more than one simple type of compound in the pathogenesis, Stem cell defects were the most common, with microenvironmental defects not uncommon; in two cases with cytostatics, the inhibition was probably from mononuclear macrophages. The elevated circulating immunocomplex (CIC) was less frequent in the CFU-F reduction group CFU-F normal group significantly increased CIC increased cases, failed to explain the elevated CIC and hematopoietic microenvironment defects related to stem cell defect-type aplastic anemia, there are two abnormalities of progenitor cells (GM-CFU; BFU -E), suggesting that the defects occurred at the level of multi-directional hematopoietic progenitor cells or more.Finally, the role of the currently used 4-component method in the pathogenesis of aplastic anemia was also evaluated and further studies Views.