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[目的]观察糖毒宁汤联合达美康片对2型糖尿病胰岛素抵抗影响疗效。[方法]使用随机平行对照方法,将80例门诊及住院患者按掷骰子法随机分为两组。达美康片,80mg/次,2次/d。对照组40例吡格列酮片,15mg/次,1次/d。治疗组40例糖毒宁汤(黄连9g,大黄、泽泻、苍术各10g,丹参、佩兰、黄芪各20g,薏苡仁30g,人参、白术、生地、葛根、淮山药、地龙、桂枝各15g),1剂/d,水煎120mL,早晚口服。连续治疗14d为1疗程。观测临床症状、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组显效25例,有效12例,无效3例,总有效率92.50%。对照组显效12例,有效15例,无效13例,总有效率67.50%。治疗组疗效优于对照组(P<0.05)。中医症状总积分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。FBG、PBG、FINS、Homa-IR、C肽水平两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.01)。血脂水平两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。炎症因子两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]糖毒宁汤联合达美康片对2型糖尿病胰岛素抵抗影响效果显著,值得推广。
[Objective] To observe the therapeutic effect of Tangji Decoction combined with Memecan Tablets on type 2 diabetes with insulin resistance. [Methods] Using randomized parallel control method, 80 outpatients and inpatients were randomly divided into two groups according to the method of dice. Deltamethrin, 80mg / time, 2 times / d. The control group 40 pioglitazone tablets, 15mg / time, 1 time / d. The treatment group, 40 cases of sugar toxin soup (Coptis 9g, rhubarb, Alisma, the herb 10g, Salvia, Perrin, Astragalus 20g, Coix 30g, ginseng, Atractylodes, Habitat, Pueraria, yam, earthworm, 15g), 1 / d, decoction 120mL, morning and evening oral. Continuous treatment 14d for a course of treatment. Observed clinical symptoms, adverse reactions. Continuous treatment of 3 courses to determine the efficacy. [Results] The treatment group markedly effective in 25 cases, effective in 12 cases, 3 cases, the total effective rate was 92.50%. The control group markedly effective in 12 cases, effective in 15 cases, ineffective in 13 cases, the total effective rate was 67.50%. The treatment group was better than the control group (P <0.05). The total score of TCM symptoms improved in both groups (P <0.01), and the treatment group improved better than the control group (P <0.01). FBG, PBG, FINS, Homa-IR and C-peptide levels improved in both groups (P <0.05, P <0.01), and improvement in treatment group was better than that in control group (P <0.01). Blood lipid levels were improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.01). Inflammatory factors were improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.01). [Conclusion] The effect of Tangji Decoction combined with Formomedicine on insulin resistance of type 2 diabetes is significant and worth promoting.