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12名30～40岁已婚妇女,6例阴道给杀精剂量醋酸棉酚-PVP泡腾片(含醋酸棉酚10mg),6例口服醋酸棉酚10mg分别在给药后1、2、4、6、8、12、24、48、96和144小时取前臂静脉血,用高效液相色谱电化学检测法测定醋酸棉酚血药浓度。该方法检测下限为5ng/ml。阴道给药者均未测得棉酚血药浓度。结果表明,单剂量醋酸棉酚-PVP泡腾片阴道给药基本不被吸收。6例口服醋酸棉酚者服药以后4.28±0.56h棉酚血药浓度达峰值,平均为340±64ng/ml,AUC为0.635±0.213mg·h/l,t_(1/2)β为77.9±44.4h,Kel 0.144±0.075h~(-1),K_(12)/K_(21)比值为5.6,符合二室模型,相关系数为0.927±0.157。口服醋酸棉酚的结果与前人报道的相似。
12 married women 30 to 40 years old, 6 cases of vaginal sperm dose of acetic acid ginsenoside-PVP effervescent tablets (containing gossypol acetate 10mg), 6 cases of oral gossypol acetate 10mg, respectively, after administration of 1,2,4 , 6,8,12,24,48,96 and 144 hours to take the forearm venous blood, Determination of acetic acid gossypol plasma concentration using high performance liquid chromatography electrochemical detection. The detection limit of this method is 5ng / ml. Vaginal administration were not measured gossypol plasma concentration. The results showed that a single dose of gossypol acetate-PVP effervescent tablets vaginal administration basically not be absorbed. The mean plasma concentrations of Gossypol at the mean of 340 ± 64ng / ml, AUC of 0.635 ± 0.213mg · h / l, t 1/2 (1/2) β were 77.9 ± 44.4h, Kel 0.144 ± 0.075h ~ (-1) and K_ (12) / K_ (21) were 5.6, which accorded with two compartment model and the correlation coefficient was 0.927 ± 0.157. Oral gossypol acetate results and previous reports of similar.