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由于美国嗜血流感杆菌脑膜炎患者中30%以上的致病菌对氨苄青霉素耐药,因而需要寻找能有效取代氨苄青霉素的抗菌药物,氯霉素虽然也是治疗嗜血流感杆菌脑膜炎的有效药物,但具有一定的毒性。本文比较氨苄青霉素与链霉素和磺胺异(口恶)唑联合应用治疗流感杆菌脑膜炎的效果。充份证实后两者药物联合应用的疗效良好、无明显毒性反应、患者容易接受,可取代氨苄青霉素、氯霉素或这两种药物的联合应用。氨节青霉素治疗61例,静注的剂量为200～400mg/kg/日。链霉素与磺胺异(口恶)唑治疗50例,链霉素第一
As more than 30% of pathogenic bacteria in the U.S. blood-borne Escherichia coli meningitis are resistant to ampicillin, there is a need to find antibacterials that can effectively replace ampicillin, although it is also used in the treatment of H. influenzae meningitis Effective drug, but with some toxicity. This article compares the efficacy of ampicillin with streptomycin and sulfonamides in the treatment of influenza Bacillus meningitis. Fully confirmed after the combination of the two drugs with good efficacy, no significant toxicity, the patient is easy to accept, can replace ampicillin, chloramphenicol or a combination of these two drugs. Ampicillin treatment of 61 cases, the intravenous dose of 200 ~ 400mg / kg / day. Streptomycin and sulfamethoxazole (oxazole) treatment of 50 cases of streptomycin first