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目的:观察甲氨蝶呤联合来氟米特治疗类风湿关节炎的临床治疗效果。方法:选取本院收治的90例类风湿关节炎病例,随机分为对照组与观察组各45例,其中对照组选用来氟米特治疗,观察组在对照组治疗基础上增加甲氨蝶呤治疗,对比分析两组临床治疗效果。结果:临床治疗总效率对比分析观察组(95.56%)显著高于对照组(84.44%),其差异有统计学意义(P<0.05)。类风湿关节炎临床症状治疗前后两组比较也具有差异性统计学意义(P<0.05)。结论:类风湿关节炎属于免疫性疾病,其发病机理复杂,治疗时选用甲氨蝶呤联合来氟米特治疗类风湿关节炎较单一用药临床疗效显著,临床症状改善明显且副作用较少,该法值得临床推广应用。
Objective: To observe the clinical effect of methotrexate combined with leflunomide in the treatment of rheumatoid arthritis. Methods: Ninety cases of rheumatoid arthritis admitted to our hospital were randomly divided into control group and observation group of 45 cases, in which the control group was treated with leflunomide, while the observation group was given methotrexate on the basis of the control group Treatment, comparative analysis of two groups of clinical treatment. Results: The total clinical efficiency of the observation group (95.56%) was significantly higher than that of the control group (84.44%), the difference was statistically significant (P <0.05). The clinical symptoms of rheumatoid arthritis before and after treatment were also statistically significant difference (P <0.05). Conclusion: Rheumatoid arthritis is an autoimmune disease with complex pathogenesis. Methotrexate combined with leflunomide is more effective than monotherapy in the treatment of rheumatoid arthritis, with obvious improvement of clinical symptoms and fewer side effects Law worthy of clinical promotion and application.