维生素C(Vc)由于分子中含有烯二醇,较易发生多种氧化降解反应,促使其注射液发黄。本文就同一注射用Vc原料在生产过程中影响变色的重要因素进行探讨。1 影响变色的因素1.1 安瓿的材质 因安瓿内壁与药液接触,互相影响,能使药液改变PH值、沉淀、变色。生产上使用中性含锆玻璃安瓿较好,其化学热稳定性、耐酸、耐碱 Vitamin C (Vc) due to the molecules containing enediol, are prone to a variety of oxidative degradation reaction, prompting the yellowing of its injection. In this paper, the same injection of Vc raw materials in the production process of the important factors affecting discoloration are discussed. 1 factors that affect discoloration 1.1 ampoule material because of ampoule wall contact with the liquid, affect each other, can change the liquid PH value, precipitation, discoloration. Production of neutral zirconium-containing glass ampoules is better, its chemical thermal stability, acid, alkali