近年来因 EB 而引起的各种副反应报道日益增多,除已为临床所公认之视神经损害外,尚有引起其他神经系统损害者,如末梢神经系统障碍、声带麻痹、听力减退以及少见的帕金森氏病。此外,还有因药物产生的过敏反应,如药物性皮疹、剥脱性皮炎、皮肤粘膜损害、嗜伊红细胞增多症、支气管痉挛致哮喘症、高热以及顽固性腹泻等。也有报道因用 EB 产生对代谢的影响而出现血钙降低、高尿酸血症等。近二年国 In recent years, due to the EB caused by a variety of side effects reported increasing, in addition to already recognized as the clinical optic nerve damage, there are other nervous system damage caused, such as peripheral nervous system disorders, vocal cord paralysis, hearing loss and rare Parkinson Disease. In addition, there are allergic reactions due to drugs, such as drug-induced rash, exfoliative dermatitis, mucocutaneous damage, eosinophilia, asthma caused by bronchospasm, fever and intractable diarrhea. It has also been reported that the use of EB produced by the metabolism of calcium decreased, hyperuricemia. Nearly two years country