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目的探讨奥沙利铂联合卡培他滨治疗老年胃肠恶性肿瘤的临床疗效。方法选取自贡市第四人民医院2014年2月—2016年8月收治的老年胃肠恶性肿瘤患者98例,按照随机数字法将患者分为对照组与观察组,各49例。对照组予以奥沙利铂+5-氟尿嘧啶化疗方案,观察组患者予以奥沙利铂+卡培他滨化疗方案,3周为1个疗程。比较两组患者临床疗效及毒副作用发生情况。结果观察组患者治疗总有效率为91.84%,高于对照组的73.47%(P<0.05)。两组患者毒副作用发生率比较,差异无统计学意义(P>0.05)。结论奥沙利铂联合卡培他滨治疗老年胃肠恶性肿瘤安全有效。
Objective To investigate the clinical efficacy of oxaliplatin plus capecitabine in the treatment of gastrointestinal malignant tumors in the elderly. Methods A total of 98 elderly patients with gastrointestinal malignant tumors who were admitted to the Fourth People’s Hospital of Zigong City from February 2014 to August 2016 were selected and divided into control group and observation group according to random number method. The control group was given oxaliplatin + 5- fluorouracil chemotherapy, and the observation group was given oxaliplatin + capecitabine chemotherapy, one course of treatment for 3 weeks. The clinical efficacy and side effects of the two groups were compared. Results The total effective rate of observation group was 91.84%, which was higher than that of control group (73.47%, P <0.05). There was no significant difference in the incidence of side effects between the two groups (P> 0.05). Conclusion Oxaliplatin combined with capecitabine is safe and effective for the treatment of gastrointestinal malignant tumors in the elderly.