观察脑卒中患者２０例使用甘露醇前后早期肾功能变化，以了解甘露醇的肾毒性作用。结果显示，使用甘露醇后，血清肌酐、尿素氮较治疗前呈上升趋势，但其差异无显著性（Ｐ＞０．０５），而血和尿中β２微球蛋白（β２－ＭＧ），α１使用微球蛋白（α１－ＭＧ），尿ＮＡＧ，γ－ＧＴ在使用甘露醇５～１０天后有明显上升（Ｐ＞０．０５），证明甘露醇有一定肾毒性作用。血和尿α１－ＭＧ，β２－ＭＧ，尿ＮＡＧ，ｒ－ＧＴ能灵敏反映早期甘露醇肾损害。 20 patients with stroke were observed before and after the use of mannitol early renal changes in order to understand the nephrotoxic effect of mannitol. The results showed that serum creatinine and blood urea nitrogen showed an upward trend after administration of mannitol, but there was no significant difference between the two groups (P> 0.05). However, β2-microglobulin (β2-MG) and α1 The use of microglobulin (α1-MG), urine NAG, γ-GT in mannitol 5 to 10 days after the significant increase (P> 0.05), to prove that mannitol has some renal toxicity. Blood and urine α1-MG, β2-MG, urine NAG, r-GT can sensitively reflect the early mannitol kidney damage.