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目的 通过对肺腺癌放射增敏的临床研究 ,探讨鹤草酚放射增敏的治疗效果。方法采用双盲法将 12 2例肺腺癌患者分为两组 ,放射增敏组病人在放疗过程中 ,每日两次口服中药提取物鹤草酚 ,对照组病人口服安慰剂。在基础因素和治疗条件大致相等的情况下 ,观察两组患者的不同治疗结果。结果 放射治疗结束时 ,增敏组病人的肿瘤完全缓解 (CR)率与对照组相比增加4 1 4 %。放疗结束后 5年内 ,增敏组患者 1,3,5年生存率与对照组相比 ,分别提高 2 3 2 %、17 2 %和12 7%。两组患者放射性肺炎的发生率和肿瘤远处转移率相比较无统计学意义 ,增敏组病人胸水发生率和病灶复发率显著低于对照组。结论 鹤草酚在对肺腺癌细胞产生放射增敏作用的同时 ,不仅对肺腺癌患者放射性肺炎的发生和肿瘤远处转移无明显影响 ,而且还能显著减少其治疗后胸水的发生和病灶的复发。
Objective To study the radiosensitization of lung adenocarcinoma and to investigate the therapeutic effect of radiosensitization of ciliolol. Methods One hundred and twenty-two patients with lung adenocarcinoma were divided into two groups by double-blind method. Patients in radiosensitization group were given oxycodone twice a day during the course of radiotherapy. Patients in the control group were given placebo orally. Under the same basic conditions and treatment conditions, observe the two groups of patients with different treatment outcomes. Results At the end of radiotherapy, the complete remission (CR) rate of patients in sensitized group increased by 41.4% compared with the control group. Within 5 years after the end of radiotherapy, the 1,3,5-year survival rates of patients in sensitized group increased by 232%, 17 2% and 12 7% respectively compared with the control group. There was no significant difference between the two groups in the incidence of radiation pneumonitis and distant metastasis of tumor. The incidence of pleural effusion and the recurrence rate of lesion in sensitized group were significantly lower than those in control group. Conclusions As the radiosensitization of lung adenocarcinoma cells is induced by oxybenzene, it not only has no significant effect on the occurrence of radiation pneumonitis and distant metastasis of tumor in lung adenocarcinoma patients, but also significantly reduces the incidence and focus of pleural effusion after treatment The recurrence.