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原发性免疫缺陷病,临床上常以迁延持续的病毒或霉菌感染为常见。现将经病理证实的二例报导与讨论如下: 例一:3个月男婴,因咳喘月余伴不规则发热于1976年4月24日入院。第4胎顺产,自生后50天左右发热,经用青霉素、链霉素治疗10天后,热稍退而出现逐渐加重之咳喘。夜间阵发哭叫伴唇周青紫,入院前唇周持续青紫,吃奶咳呛,气促加剧。体检:T37.2℃(A)、R 60/分、P 160/分、发育欠佳,神萎,痛苦面容,皮下脂肪大部消失,面色灰暗,唇周紫绀,略有鼻搧,前囱平,颈软,气管居中,全身浅淋巴结不肿大,心尖搏动最强点延伸至在乳头线之外,心音低钝,未闻杂音,心律齐、心率160次/分,右上肺叩浊,右下肺叩响增强,右肺中部可闻密集中小湿罗音,腹软。可见肠型,肝肋下平脐、质软,脾未触及,两下肢轻度可凹性浮肿,神经系检查阴性。
Primary immunodeficiency disease, often clinically persistent persistent virus or fungal infections are common. Now confirmed by the pathology of the two cases reported and discussed as follows: Example 1: 3-month-old boy, due to cough and month with irregular fever admitted in April 24, 1976. The first 4 births, spontaneous after about 50 days fever, after penicillin, streptomycin treatment for 10 days, the heat slightly back and gradually increased cough and asthma. Cry burst at night with lip Zhou Qing Zi, lip weeks before admission continued bruising, cough, choking, irritability increased. Physical examination: T37.2 ℃ (A), R60 / min, P160 / min, poor development, atrophy, painful face, subcutaneous fat most disappear, pale, lip cyanosis, a slight nose fan, the former Flat, soft neck, tracheal center, systemic superficial lymph nodes is not swollen, the strongest point of apex beating extends to the nipple line, low heart sound blunt, unheard noise, heart rate Qi, heart rate 160 beats / min, Lower right lung knock knock increased, the central part of the right lung can be concentrated in small humid Luo sound, abdominal soft. Visible intestinal type, the ribs under the ribs plain umbilical, soft, spleen not touched, two lower limbs mild concave edema, negative neurological examination.