母-胎界面免疫调节功能的异常是导致复发性流产(recurrent spontaneous abortion,RSA)的一个重要病因,其作用机制尚不清楚。趋化因子及其受体参与调控母-胎界面免疫细胞的定向招募和活化,在免疫耐受状态的维持、新血管的生成、滋养层细胞的增殖和侵袭过程中发挥重要作用。因此,母-胎界面趋化因子及其受体功能的异常,可能会打破免疫耐受状态,导致胚胎植入和胎盘形成障碍,从而引起流产。 Abnormality of immunomodulatory function at the maternal-fetal interface is an important cause of recurrent spontaneous abortion (RSA), and its mechanism of action is not yet clear. Chemokines and their receptors are involved in the regulation of directional recruitment and activation of immune cells at the maternal-fetal interface and play an important role in the maintenance of immune tolerance, the generation of new blood vessels, the proliferation and invasion of trophoblast cells. Thus, abnormalities in maternal-fetal interface chemokine and its receptor function may disrupt immune tolerance, leading to embryo implantation and placental disorders, leading to miscarriage.