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高迁移率族蛋白B1(high mobility group box1 protein,HMGB1)是一种核蛋白质,其可由坏死细胞以及活化的免疫细胞释放至细胞外而具有细胞因子的活性,继之启动免疫反应和引发炎性反应。近年来,大量研究证实HMGB1与心力衰竭(heart failure,HF)、心肌缺血-再灌注(ischemia/reperfusion,I/R)损伤、动脉粥样硬化(atherosclerosis,AS)、心肌梗死(myo-cardial infarction,MI)等疾病有密切关系,通过研究HMGB1在心血管疾病发生发展过程中的机制,可为心血管疾病的临床治疗找到新靶点。
High mobility group box1 protein (HMGB1) is a nuclear protein that has cytokine activity released by necrotic cells and activated immune cells to the outside of the cell, followed by the initiation of immune responses and the initiation of inflammatory reaction. In recent years, a large number of studies have demonstrated that HMGB1 is associated with heart failure (HF), myocardial ischemia-reperfusion (I / R) injury, atherosclerosis (AS), myo- cardial infarction, MI) and other diseases are closely related. By studying the mechanism of HMGB1 in the development and progression of cardiovascular diseases, new targets can be found for the clinical treatment of cardiovascular diseases.