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近年来屡见卡托普利(captopril,CPT,巯甲丙脯酸)不良反应的报道,现就其产生耐受性二例报道如下。 例1 女,66岁。高血压史23年,间断口服复方降压片及心痛定治疗。头痛、头晕伴恶心2天于1991年2月8日来诊。血压29.3/16kPa(220/120mmHg),心电图示心肌供血不足。给予CPT(中美上海施贵宝制药有限公司生产,批号9008079)12.5mg日3次;一周后增至25mg,日三次。症状消失,血压稳定在21.3～22.7/11.9～13.3kPa(160～170/89～100mmHg),继续服用维持量。1年后不明原因出现周身不适、困倦、头胀痛、恶心,血压32/16kPa(240/120mmHg),先后将C-
In recent years, frequent reports of captopril (captopril, CPT, captopril) adverse reactions are now reported on the two were reported as follows. Example 1 Female, 66 years old. Hypertension for 23 years, intermittent oral compound antihypertensive tablets and nifedipine treatment. Headache, dizziness with nausea 2 days in February 8, 1991 visit. Blood pressure 29.3 / 16kPa (220 / 120mmHg), ECG shows myocardial insufficiency. Give CPT (Sino-US Shanghai Squibb Pharmaceutical Co., Ltd. production, batch number 9008079) 12.5mg day 3 times; a week later increased to 25mg, 3 times a day. Symptoms disappeared, blood pressure stabilized at 21.3 ~ 22.7 / 11.9 ~ 13.3kPa (160 ~ 170/89 ~ 100mmHg), continue to take the maintenance dose. 1 year after the unidentified cause of discomfort, drowsiness, head pain, nausea, blood pressure 32 / 16kPa (240 / 120mmHg), the C-